പാരസെറ്റാമോൾ

വിക്കിപീഡിയ, ഒരു സ്വതന്ത്ര വിജ്ഞാനകോശം.
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പാരസെറ്റാമോൾ
Paracetamol-skeletal.svg
Paracetamol-from-xtal-3D-balls.png
Systematic (IUPAC) name
N-(4-hydroxyphenyl)ethanamide
N-(4-hydroxyphenyl)acetamide
Clinical data
PronunciationParacetamol: /ˌpærəˈsɛtəmɒl/
Acetaminophen: /əˌstəˈmɪnəf[invalid input: 'ɨ']n/ (About this soundശ്രവിക്കുക)
Trade namesTylenol, Panadol, others[1]
AHFS/Drugs.commonograph
MedlinePlusa681004
License data
Pregnancy
category
  • AU: A
  • US: C (Risk not ruled out)
  • Not tested but seems to be safe
Routes of
administration
By mouth, through the cheek, rectal, intravenous (IV)
Legal status
Legal status
Pharmacokinetic data
Bioavailability63–89%[2]:73
Protein binding10–25%[3]
MetabolismPredominantly in the liver[4]
MetabolitesAPAP gluc, APAP sulfate, NAPQI, APAP-GSH, APAP-cys[5]
Onset of actionPain relief onset by route:
By mouth – 37 minutes[6]
Buccal – 15 minutes[6]
Intravenous – 8 minutes[6]
Biological half-life1–4 hours[4]
ExcretionUrine (85–90%)[4]
Identifiers
CAS Number103-90-2 ☑Y
ATC codeN02BE01 (WHO)
PubChemCID 1983
IUPHAR/BPS5239
DrugBankDB00316 ☑Y
ChemSpider1906 ☑Y
UNII362O9ITL9D ☑Y
KEGGD00217 ☑Y
ChEBICHEBI:46195 ☑Y
ChEMBLCHEMBL112 ☑Y
PDB ligand IDTYL (PDBe, RCSB PDB)
Chemical data
FormulaC8H9NO2
Molar mass151.163 g/mol
Physical data
Density1.263 g/cm3
Melting point169 °C (336 °F) [8][9]
Boiling point420 °C (788 °F)
Solubility in water7.21 g/kg (0 °C)[7]

8.21 g/kg (5 °C)[7]
9.44 g/kg (10 °C)[7]
10.97 g/kg (15 °C)[7]
12.78 g/kg (20 °C)[7]

~14 mg/mL (20 °C)
  (verify)

പനിയ്ക്കും ശരീരവേദനയ്ക്കും ഉപയോഗിക്കുന്ന ഒരു ഔഷധമിശ്രണമാണു് പാരസെറ്റമോൾ. അസറ്റാമൈനോഫിൻ എന്നും അറിയപ്പെടുന്നു.


അനുബന്ധം[തിരുത്തുക]

  1. "International Listings for Paracetamol". ശേഖരിച്ചത് 11 January 2016. CS1 maint: discouraged parameter (link)
  2. Working Group of the Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine (2010). Macintyre, PE; Schug, SA; Scott, DA; Visser, EJ; Walker, SM (eds.). Acute Pain Management: Scientific Evidence (PDF) (3rd ed.). Melbourne, Australia: National Health and Medical Research Council. ISBN 9780977517459.
  3. "Tylenol, Tylenol Infants' Drops (acetaminophen) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. ശേഖരിച്ചത് 10 May 2014. CS1 maint: discouraged parameter (link)
  4. 4.0 4.1 4.2 "Codapane Forte Paracetamol and codeine phosphate PRODUCT INFORMATION" (PDF). TGA eBusiness Services. Alphapharm Pty Limited. 29 April 2013. ശേഖരിച്ചത് 10 May 2014. CS1 maint: discouraged parameter (link)
  5. "Acetaminophen Pathway (therapeutic doses), Pharmacokinetics". ശേഖരിച്ചത് 13 January 2016. CS1 maint: discouraged parameter (link)
  6. 6.0 6.1 6.2 Pickering G, Macian N, Libert F, Cardot JM, Coissard S, Perovitch P, Maury M, Dubray C (September 2014). "Buccal acetaminophen provides fast analgesia: two randomized clinical trials in healthy volunteers". Drug Des. Devel. Ther. 8: 1621–1627. doi:10.2147/DDDT.S63476. PMC 4189711. PMID 25302017. bAPAP has a faster time of antinociception onset (15 minutes, P<0.01) and greater antinociception at 50 minutes (P<0.01, CT1) and 30 minutes (P<0.01, CT2) than ivAPAP and sAPAP. All routes are similar after 50 minutes. ... In postoperative conditions for acute pain of mild to moderate intensity, the quickest reported time to onset of analgesia with APAP is 8 minutes9 for the iv route and 37 minutes6 for the oral route.
  7. 7.0 7.1 7.2 7.3 7.4 Granberg RA, Rasmuson AC (1999). "Solubility of paracetamol in pure solvents". Journal of Chemical & Engineering Data. 44 (6): 1391–95. doi:10.1021/je990124v.
  8. Karthikeyan, M.; Glen, R. C.; Bender, A. (2005). "General Melting Point Prediction Based on a Diverse Compound Data Set and Artificial Neural Networks". Journal of Chemical Information and Modeling. 45 (3): 581–590. doi:10.1021/ci0500132. PMID 15921448.
  9. "melting point data for paracetamol". Lxsrv7.oru.edu. ശേഖരിച്ചത് 19 March 2011. CS1 maint: discouraged parameter (link)
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