പ്രൊജസ്റ്റീറോൺ റിസപ്റ്റർ

PGR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4OAR, 1A28, 1E3K, 1SQN, 1SR7, 1ZUC, 2C7A, 2OVH, 2OVM, 2W8Y, 3D90, 3G8O, 3HQ5, 3KBA, 3ZR7, 3ZRA, 3ZRB, 4A2J, 4APU, 5CC0
Identifiers
Aliases	PGR, NR3C3, PR, progesterone receptor
External IDs	OMIM: 607311 MGI: 97567 HomoloGene: 713 GeneCards: PGR
Gene location (Human)
Chr.	Chromosome 11 (human)
End	101,129,813 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	8,968,612 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • sequence-specific DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • ATPase binding; • zinc ion binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • metal ion binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • steroid hormone receptor activity; • steroid binding; • GO:0001948, GO:0016582 protein binding; • enzyme binding; • signaling receptor binding; • lipid binding; • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity; • identical protein binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	• കോശദ്രവ്യം; • membrane; • nucleoplasm; • mitochondrial outer membrane; • മൈറ്റോകോൺട്രിയ; • കോശമർമ്മം; • സൈറ്റോസോൾ;
Biological process	• GO:0009373 regulation of transcription, DNA-templated; • cell-cell signaling; • negative regulation of gene expression; • transcription, DNA-templated; • transcription initiation from RNA polymerase II promoter; • GO:0072468 signal transduction; • steroid hormone mediated signaling pathway; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • ovulation from ovarian follicle; • epithelial cell maturation; • mammary gland development; • paracrine signaling; • lung alveolus development; • regulation of epithelial cell proliferation; • progesterone receptor signaling pathway; • tertiary branching involved in mammary gland duct morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	5241
	18667
	ENSG00000082175
	ENSMUSG00000031870
	P06401
	Q00175
	NM_000926; NM_001202474; NM_001271161; NM_001271162
	NM_008829
	NP_000917; NP_001189403; NP_001258090; NP_001258091
	NP_032855
	Wikidata
View/Edit Human	View/Edit Mouse

കോശങ്ങൾക്കുള്ളിൽ കാണപ്പെടുന്ന ഒരു പ്രോട്ടീനാണ് പ്രോജസ്സ്റ്റീറോൺ റിസപ്റ്റർ ( പിആർ ), NR3C3 അല്ലെങ്കിൽ ന്യൂക്ലിയർ റിസപ്റ്റർ സബ്ഫാമിലി 3 എന്നും അറിയപ്പെടുന്നു, ഗ്രൂപ്പ് സി, അംഗം 3. പ്രോജസ്റ്ററോൺ എന്ന സ്റ്റിറോയിഡ് ഹോർമോണാണ് ഇത് സജീവമാക്കുന്നത്.

മനുഷ്യരിൽ, 11q 22 ക്രോമസോമിൽ വസിക്കുന്ന ഒരൊറ്റ PGR ജീൻ ഉപയോഗിച്ചാണ് ഈ റിസപ്റ്ററുകൾ എൻകോഡ് ചെയ്യുന്നത്, ^[5] ^[6] ^[7] ഇതിന് PR-A, PR-B എന്നീ രണ്ട് ഐസോഫോമുകൾ ഉണ്ട്, അത് അവയുടെ തന്മാത്രാ ഭാരത്തിൽ വ്യത്യാസമുണ്ട്. ^[8] ^[9] ^[10] PR-B പ്രോജസ്റ്ററോണിന്റെ ഫലങ്ങളുടെ പോസിറ്റീവ് റെഗുലേറ്ററാണ്, അതേസമയം PR-A റിസപ്റ്ററുകൾ PR-B യുടെ ഫലങ്ങളെ എതിർക്കുന്നു. ^[11]

റഫറൻസുകൾ[തിരുത്തുക]

↑ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000082175 - Ensembl, May 2017
↑ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000031870 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA". Biochemical and Biophysical Research Communications. 143 (2): 740–8. March 1987. doi:10.1016/0006-291X(87)91416-1. PMID 3551956.
↑ "The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2". Proceedings of the National Academy of Sciences of the United States of America. 84 (9): 2877–81. May 1987. Bibcode:1987PNAS...84.2877L. doi:10.1073/pnas.84.9.2877. PMC 304763. PMID 3472240.
↑ ensembl.org, Gene: ESR1 (ENSG00000091831)
↑ "Progesterone receptors: various forms and functions in reproductive tissues". Frontiers in Bioscience. 10 (1–3): 2118–30. 2005. doi:10.2741/1685. PMID 15970482.
↑ Kase, Nathan G.; Speroff, Leon; Glass, Robert L. (1999). Clinical gynecologic endocrinology and infertility. Hagerstown, MD: Lippincott Williams & Wilkins. ISBN 978-0-683-30379-7.
↑ Fritz, Marc A.; Speroff, Leon (2005). Clinical gynecologic endocrinology and infertility. Hagerstown, MD: Lippincott Williams & Wilkins. ISBN 978-0-7817-4795-0.
↑ Falcone, Tommaso; Hurd, William W. (22 May 2013). Clinical Reproductive Medicine and Surgery: A Practical Guide. Springer Science & Business Media. pp. 39–. ISBN 978-1-4614-6837-0.

പുറത്തേക്കുള്ള കണ്ണികൾ[തിരുത്തുക]

MeSH Progesterone+Receptors

ഫലകം:PDB Gallery

ഫലകം:Progestogenics ഫലകം:InterPro content

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000082175 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000031870 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid3551956-5] "Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA". Biochemical and Biophysical Research Communications. 143 (2): 740–8. March 1987. doi:10.1016/0006-291X(87)91416-1. PMID 3551956.

[pmid3472240-6] "The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2". Proceedings of the National Academy of Sciences of the United States of America. 84 (9): 2877–81. May 1987. Bibcode:1987PNAS...84.2877L. doi:10.1073/pnas.84.9.2877. PMC 304763. PMID 3472240.

[7] sembl.org, Gene: ESR1 (ENSG00000091831)

[pmid15970482-8] "Progesterone receptors: various forms and functions in reproductive tissues". Frontiers in Bioscience. 10 (1–3): 2118–30. 2005. doi:10.2741/1685. PMID 15970482.

[isbn0-683-30379-1-9] Kase, Nathan G.; Speroff, Leon; Glass, Robert L. (1999). Clinical gynecologic endocrinology and infertility. Hagerstown, MD: Lippincott Williams & Wilkins. ISBN 978-0-683-30379-7.

[isbn0-7817-4795-3-10] Fritz, Marc A.; Speroff, Leon (2005). Clinical gynecologic endocrinology and infertility. Hagerstown, MD: Lippincott Williams & Wilkins. ISBN 978-0-7817-4795-0.

[FalconeHurd2013-11] Falcone, Tommaso; Hurd, William W. (22 May 2013). Clinical Reproductive Medicine and Surgery: A Practical Guide. Springer Science & Business Media. pp. 39–. ISBN 978-1-4614-6837-0.

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