സുഖം, ഉത്സാഹം, ക്ഷേമം, സന്തോഷം തുടങ്ങിയ തീവ്ര വികാരങ്ങളുടെ അനുഭവമാണ് യുഫോറിയ. എയറോബിക് വ്യായാമം, ചിരി, സംഗീതം കേൾക്കൽ, നൃത്തം തുടങ്ങി ചില സ്വാഭാവിക പ്രതിഫലനവും സാമൂഹിക പ്രവർത്തനങ്ങളും വഴി യുഫോറിയ അവസ്ഥ സൃഷ്ടിക്കാൻ കഴിയും.യുഫോറിയ ചില ന്യൂറോളജിക്കൽ ഡിസോർഡർ അല്ലെങ്കിൽ ന്യൂറോ സൈക്കിയാട്രിക് ഡിസോർഡേഴ്സിന്റേയും ലക്ഷണമാണ്. ഉദാഹരണത്തിന് മാനിയ
- Bearn J, O'Brien M (2015). ""Addicted to Euphoria": The History, Clinical Presentation, and Management of Party Drug Misuse". Int. Rev. Neurobiol. 120: 205–33. doi:10.1016/bs.irn.2015.02.005. PMID 26070759.
Eating, drinking, sexual activity, and parenting invoke pleasure, an emotion that promotes repetition of these behaviors, are essential for survival. Euphoria, a feeling or state of intense excitement and happiness, is an amplification of pleasure, aspired to one's essential biological needs that are satisfied. People use party drugs as a shortcut to euphoria. Ecstasy (3,4-methylenedioxymethamphetamine), γ-hydroxybutyric acid, and ketamine fall under the umbrella of the term "party drugs," each with differing neuropharmacological and physiological actions.
- Alcaro A, Panksepp J (2011). "The SEEKING mind: primal neuro-affective substrates for appetitive incentive states and their pathological dynamics in addictions and depression". Neuroscience and Biobehavioral Reviews. 35 (9): 1805–1820. doi:10.1016/j.neubiorev.2011.03.002. PMID 21396397.
Recent human data have demonstrated that the SEEKING brain circuitry, as predicted, is involved in the emergence of a characteristic appetitive affective state, which may be described as “enthusiastic positive excitement” or “euphoria” (Drevets et al., 2001; Volkow and Swanson, 2003) and that do not resemble any kind of sensory pleasure (Heath, 1996; Panksepp et al., 1985) ... However, in our view, cognitive processes, are only one “slice of the pie”, and gamma oscillations may be more globally viewed as the overall emotional–motivational neurodynamics through which the SEEKING disposition is expressed, accompanied by a feeling of excitement/eurphoria (not ‘pleasure’) that is evolutionarily designed to achieve a diversity of useful outcomes
- "Key DSM-IV Mental Status Exam Phrases". Gateway Psychiatric Services. Mood and Affect. Archived from the original on 13 November 2013. Retrieved 17 February 2014.
- Cohen EE, Ejsmond-Frey R, Knight N, Dunbar RI (2010). "Rowers' high: behavioural synchrony is correlated with elevated pain thresholds". Biol. Lett. 6 (1): 106–8. doi:10.1098/rsbl.2009.0670. PMC 2817271. PMID 19755532.
This heightened effect from synchronized activity may explain the sense of euphoria experienced during other social activities (such as laughter, music-making and dancing) that are involved in social bonding in humans and possibly other vertebrates.
- Malenka RC, Nestler EJ, Hyman SE (2009). Sydor A, Brown RY, eds. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.). New York: McGraw-Hill Medical. pp. 191, 350–351, 367–368, 371–375. ISBN 9780071481274. "Changes in appetite and energy may reflect abnormalities in various hypothalamic nuclei. Depressed mood and anhedonia (lack of interest in pleasurable activities) in depressed individuals, and euphoria and increased involvement in goal-directed activities in patients, who experience mania, may reflect opposing abnormalities in the nucleus accumbens, medial prefrontal cortex, amygdala, or other structures. ... Although short-term administration of glucocorticoids often produces euphoria and increased energy, the impact of long-lasting increases in endogenous glucocorticoids produced during depression can involve complex adaptations such as those that occur in Cushing syndrome (Chapter 10). ... Exposure to addictive chemicals not only produces extreme euphoric states that may initially motivate drug use, but also causes equally extreme adaptations in reinforcement mechanisms and motivated behavior that eventually lead to compulsive use. Accordingly, the evolutionary design of human and animal brains that has helped to promote our survival also has made us vulnerable to addiction."