പ്രോസ്റ്റാഗ്ലാൻഡിൻ EP3 റിസപ്റ്റർ

ഇംഗ്ലീഷ് വിലാസം

https://ml.wikipedia.org/wiki/Prostaglandin_EP3_receptor

PTGER3
Identifiers
Aliases	PTGER3, EP3, EP3-I, EP3-II, EP3-III, EP3-IV, EP3e, PGE2-R, EP3-VI, Prostaglandin E receptor 3, lnc003875
External IDs	OMIM: 176806 MGI: 97795 HomoloGene: 105703 GeneCards: PTGER3
Gene location (Human) Chr. Chromosome 1 (human) Band 1p31.1 Start 70,852,353 bp End 71,047,816 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 H4|3 81.32 cM Start 157,272,529 bp End 157,351,525 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • G protein-coupled receptor activity • prostaglandin receptor activity • signal transducer activity • prostaglandin E receptor activity • GO:0001948, GO:0016582 protein binding Cellular component • nuclear envelope • membrane • കോശസ്തരം • integral component of plasma membrane • integral component of membrane Biological process • G protein-coupled receptor signaling pathway • positive regulation of fever generation • cell death • GO:0072468 signal transduction • negative regulation of gastric acid secretion • phospholipase C-activating G protein-coupled receptor signaling pathway • intestine smooth muscle contraction • inflammatory response • adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5733	19218
Ensembl	ENSG00000050628	ENSMUSG00000040016
UniProt	P43115	P30557
RefSeq (mRNA)	NM_000957 NM_001126044 NM_198712 NM_198713 NM_198714 NM_198715 NM_198716 NM_198717 NM_198718 NM_198719 NM_198720	NM_011196 NM_001359745
RefSeq (protein)	NP_001119516 NP_942007 NP_942008 NP_942009 NP_942010 NP_942011 NP_942012	n/a
Location (UCSC)	Chr 1: 70.85 – 71.05 Mb	Chr 3: 157.27 – 157.35 Mb
PubMed search
Wikidata
View/Edit Human View/Edit Mouse

പ്രോസ്റ്റാഗ്ലാൻഡിൻ EP3 റിസപ്റ്റർ (53kDa), ഇപി 3 എന്നും അറിയപ്പെടുന്നു, മനുഷ്യ ജീൻ PTGER3 എൻകോഡ് ചെയ്തിട്ടുള്ള പ്രോസ്റ്റാഗ്ലാൻഡിൻ E2 (PGE2) പ്രോസ്റ്റാഗ്ലാൻഡിൻ റിസപ്റ്റർ ആണ്.ഇത് തിരിച്ചറിഞ്ഞിട്ടുള്ള നാല് ഇപി റിസപ്റ്ററുകളിൽ ഒന്നാണ്. മറ്റുള്ളവ EP1, EP2, EP4 എന്നിവയാണ്. ഇവയെല്ലാം PGE2- നും സെല്ലുലാർ പ്രതികരണങ്ങളുമായി ബന്ധിപ്പിക്കുകയും മധ്യസ്ഥം ആയി പ്രതിപ്രവർത്തിക്കുകയും ചെയ്യുന്നു. എന്നാൽ പൊതുവേ ചെറിയ ഘടനാസാദൃശ്യവും പ്രതികരണവുമൊക്കെയുള്ള പ്രോസ്റ്റാനോയിഡുകൾ (പ്രോസ്റ്റാഗ്ലാൻഡിൻ റിസപ്റ്റർ കാണുക).ആണ്. ഇപി വിവിധതരം ശാരീരികവും രോഗകാരകവുമായ പ്രതികരണങ്ങളെ സൂചിപ്പിക്കുന്നു.

ഇതും കാണുക

• Eicosanoid receptor
• Prostaglandin E2 receptor 1 (EP1)
• Prostaglandin E2 receptor 2 (EP2)
• Prostaglandin E2 receptor 4 (EP4)

കൂടുതൽ വായനയ്ക്ക്

• Kotani M, Tanaka I, Ogawa Y, Usui T, Mori K, Ichikawa A, Narumiya S, Yoshimi T, Nakao K (November 1995). "Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions". Molecular Pharmacology. 48 (5): 869–79. PMID 7476918.
• Han X, Lan X, Li Q, Gao Y, Zhu W, Cheng T, Maruyama T, Wang J (June 2016). "Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin-induced brain injury". Journal of Cerebral Blood Flow and Metabolism. 36 (6): 1059–74. doi:10.1177/0271678X15606462. PMID 26661165.
• Duncan AM, Anderson LL, Funk CD, Abramovitz M, Adam M (February 1995). "Chromosomal localization of the human prostanoid receptor gene family". Genomics. 25 (3): 740–2. doi:10.1016/0888-7543(95)80022-E. PMID 7759114.
• Schmid A, Thierauch KH, Schleuning WD, Dinter H (February 1995). "Splice variants of the human EP3 receptor for prostaglandin E2". European Journal of Biochemistry. 228 (1): 23–30. doi:10.1111/j.1432-1033.1995.tb20223.x. PMID 7883006.
• An S, Yang J, So SW, Zeng L, Goetzl EJ (December 1994). "Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals". Biochemistry. 33 (48): 14496–502. doi:10.1021/bi00252a016. PMID 7981210.
• Regan JW, Bailey TJ, Donello JE, Pierce KL, Pepperl DJ, Zhang D, Kedzie KM, Fairbairn CE, Bogardus AM, Woodward DF (June 1994). "Molecular cloning and expression of human EP3 receptors: evidence of three variants with differing carboxyl termini". British Journal of Pharmacology. 112 (2): 377–85. doi:10.1111/j.1476-5381.1994.tb13082.x. PMC 1910333. PMID 8075855.
• Yang J, Xia M, Goetzl EJ, An S (February 1994). "Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2". Biochemical and Biophysical Research Communications. 198 (3): 999–1006. doi:10.1006/bbrc.1994.1142. PMID 8117308.
• Kunapuli SP, Fen Mao G, Bastepe M, Liu-Chen LY, Li S, Cheung PP, DeRiel JK, Ashby B (March 1994). "Cloning and expression of a prostaglandin E receptor EP3 subtype from human erythroleukaemia cells". The Biochemical Journal. 298 (2): 263–7. doi:10.1042/bj2980263. PMC 1137934. PMID 8135729.
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• Chang C, Negishi M, Nishigaki N, Ichikawa A (March 1997). "Functional interaction of the carboxylic acid group of agonists and the arginine residue of the seventh transmembrane domain of prostaglandin E receptor EP3 subtype". The Biochemical Journal. 322 (2): 597–601. doi:10.1042/bj3220597. PMC 1218231. PMID 9065782.
• Kotani M, Tanaka I, Ogawa Y, Usui T, Tamura N, Mori K, Narumiya S, Yoshimi T, Nakao K (March 1997). "Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3)". Genomics. 40 (3): 425–34. doi:10.1006/geno.1996.4585. PMID 9073510.
• Ushikubi F, Segi E, Sugimoto Y, Murata T, Matsuoka T, Kobayashi T, Hizaki H, Tuboi K, Katsuyama M, Ichikawa A, Tanaka T, Yoshida N, Narumiya S (September 1998). "Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3". Nature. 395 (6699): 281–4. doi:10.1038/26233. PMID 9751056.
• Bhattacharya M, Peri K, Ribeiro-da-Silva A, Almazan G, Shichi H, Hou X, Varma DR, Chemtob S (May 1999). "Localization of functional prostaglandin E2 receptors EP3 and EP4 in the nuclear envelope". The Journal of Biological Chemistry. 274 (22): 15719–24. doi:10.1074/jbc.274.22.15719. PMID 10336471.
• Liu J, Akahoshi T, Jiang S, Namai R, Kitasato H, Endo H, Kameya T, Kondo H (August 2000). "Induction of neutrophil death resembling neither apoptosis nor necrosis by ONO-AE-248, a selective agonist for PGE2 receptor subtype 3". Journal of Leukocyte Biology. 68 (2): 187–93. PMID 10947062.
• Kurihara Y, Endo H, Kondo H (January 2001). "Induction of IL-6 via the EP3 subtype of prostaglandin E receptor in rat adjuvant-arthritic synovial cells". Inflammation Research. 50 (1): 1–5. doi:10.1007/s000110050716. PMID 11235015.
• Matsuoka Y, Furuyashiki T, Bito H, Ushikubi F, Tanaka Y, Kobayashi T, Muro S, Satoh N, Kayahara T, Higashi M, Mizoguchi A, Shichi H, Fukuda Y, Nakao K, Narumiya S (April 2003). "Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes". Proceedings of the National Academy of Sciences of the United States of America. 100 (7): 4132–7. doi:10.1073/pnas.0633341100. PMC 153060. PMID 12642666.
• Wing DA, Goharkhay N, Hanna M, Naidu YM, Kovacs BW, Felix JC (April 2003). "EP3-2 receptor mRNA expression is reduced and EP3-6 receptor mRNA expression is increased in gravid human myometrium". Journal of the Society for Gynecologic Investigation. 10 (3): 124–9. doi:10.1016/S1071-5576(03)00007-8. PMID 12699873.
• Abulencia JP, Gaspard R, Healy ZR, Gaarde WA, Quackenbush J, Konstantopoulos K (August 2003). "Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells". The Journal of Biological Chemistry. 278 (31): 28388–94. doi:10.1074/jbc.M301378200. PMID 12743126.
• Richards JA, Brueggemeier RW (June 2003). "Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes". The Journal of Clinical Endocrinology and Metabolism. 88 (6): 2810–6. doi:10.1210/jc.2002-021475. PMID 12788892.
• Moreland RB, Kim N, Nehra A, Goldstein I, Traish A (October 2003). "Functional prostaglandin E (EP) receptors in human penile corpus cavernosum". International Journal of Impotence Research. 15 (5): 362–8. doi:10.1038/sj.ijir.3901042. PMID 14562138.

ബാഹ്യ ലിങ്കുകൾ

• "Prostanoid Receptors: EP₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-06-29.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.